Depression at Thalamocortical Synapses
نویسندگان
چکیده
منابع مشابه
Depression at Thalamocortical Synapses The Key for Cortical Neuronal Adaptation?
Neuronal adaptation to repetitive sensory stimuli is ubiquitous in the mammalian cortex. Despite its prevalence, the cellular mechanisms underlying this basic physiological property remain a matter of dispute. In this issue of Neuron, Chung et al. provide conclusive evidence that depression of thalamocortical synapses may play a significant role in the expression of neuronal adaptation in the r...
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We examine the effects of short-term synaptic depression on the orientation tuning of the LGN input to simple cells in cat primary visual cortex (V1). The total LGN input has an untuned component as well as a tuned component, both of which grow with stimulus contrast. The untuned component is not visible in the firing rate responses of the simple cells. The suppression of the contribution of th...
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In vivo whole-cell recordings revealed that during repeated stimulation, synaptic responses to deflection of facial whiskers rapidly adapt. Extracellular recordings in the somatosensory thalamus revealed that part of the adaptation occurs subcortically, but because cortical adaptation is stronger and recovers more slowly, cortical mechanisms must also contribute. Trains of sensory stimuli that ...
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Sensory experience during an early critical period guides the development of thalamocortical circuits in many cortical areas. This process has been hypothesized to involve long-term potentiation (LTP) and long-term depression (LTD) at thalamocortical synapses. Here, we show that thalamocortical synapses in rat barrel cortex can express LTD, and that LTD is most readily induced during a developm...
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Thalamocortical (TC) projections provide the major pathway for ascending sensory information to the mammalian neocortex. Arrays of these projections form synaptic inputs on thalamorecipient neurons, thus contributing to the formation of receptive fields (RFs) in sensory cortices. Experience-dependent plasticity of RFs persists throughout an organism's life span but in adults requires activation...
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ژورنال
عنوان ژورنال: Neuron
سال: 2002
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(02)00691-8